UBD anticorps (AA 80-130)

N° du produit ABIN6992138

L’anticorps Lapin Polyclonal anti-UBD a été validé pour WB, ELISA, IF et IHC (p). Il convient pour détecter UBD dans des échantillons de Humain.

Aperçu rapide pour UBD anticorps (AA 80-130) (ABIN6992138)

Antigène: UBD (Ubiquitin D (UBD))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp UBD est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-UBD anticorps

Épitope: AA 80-130

Specificité: UBD antibody is human specific.

Purification: UBD antibody is affinity chromatography purified via peptide column.

Immunogène: UBD antibody was raised against a 16 amino acid peptide near the center of human UBD. The immunogen is located within amino acids 80 - 130 of UBD.

Isotype: IgG

Information d'application

Indications d'application: UBD antibody can be used for detection of UBD by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: UBD antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: UBD antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Détails sur UBD

Antigène: UBD (Ubiquitin D (UBD))

Autre désignation: UBD

Sujet: UBD, also designated ubiquitin D or diubiquitin, plays a role in antigen presentation, cytokine response and apoptosis. It is a 165 amino acid protein encoded in the major histocompatibility complex (MHC) that consists of two domains which share significant homology with ubiquitin (1,2). UBD is inducible by interferon gamma and TNF-alpha and regulates TNF-alpha-induced and LPS-mediated activation of the central mediator of innate immunity NF-kappa-B by promoting TNF-alpha-mediated proteasomal degradation of ubiquitinated-I-kappa-B-alpha (3). It may also regulate cell growth during dendritic cell or B cell activation and development (4,5).

Poids moléculaire: Predicted: 18 kDa

Observed: 17 kDa

ID gène: 10537

NCBI Accession: NP_006389

UniProt: O15205

Pathways: Ubiquitin Proteasome Pathway